DAY 1

07.35 – 08.20 REGISTRATION
08.20 – 08.30 WELCOME & CHAIRPERSON’S OPENING REMARKS FOR DAY ONE

08.30 – 09.00

Platform fit for the non-platform molecules: simultaneous innovation of platform and process

• Merck has a drug substance manufacturing platform for biologics with state-of-the-art facilities that prioritize green and sustainable practices.

• Technological advances are integrated to manage the complexity of next-generation biologics.

• Platform fit for the non-platform molecules are discussed in case studies.

 

09.00 – 09.30

Implementing Filtration Technologies for Both Upstream and Downstream Unit Operations in Continuous Biomanufacturing

• Filtration plays critical roles in upstream and downstream continuous processing and presents unique challenges compared to traditional batch
manufacturing.

• Perfusion cell culture requires highly optimized filtration operations to ensure a high degree of product recovery while maintaining high through- put and cell viability.

• Continuous virus filtration (VF) is performed at a much lower flux and much higher throughput than most batch operations, presenting challenges
for both filter fouling and viral clearance.

 

Downstream Development

• Filtration plays critical roles in upstream and downstream continuous processing and presents unique challenges compared to traditional batch
manufacturing.

• Perfusion cell culture requires highly optimized filtration operations to ensure a high degree of product recovery while maintaining high through- put and cell viability.

 

 

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